Related Experiment Video

Updated: Jul 25, 2025

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
08:47

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

Published on: May 1, 2020

3.1K

Molecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics

Jia Song1, Yuexin Ge1, Mingyan Dong1

  • 1Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, China Medical University, Shenyang, 110122, PR China.

European Journal of Pharmacology
|June 27, 2023
PubMed

Insights

The eukaryotic translation initiation factor 4 (EIF4) family impacts cancer development. Circular RNAs (circRNAs) interact with EIF4s, offering potential therapeutic targets for cancer treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • The eukaryotic translation initiation factor 4 (EIF4) family is crucial for mRNA recruitment to ribosomes, playing a key role in eukaryotic translation.
  • Dysregulation of EIF4 family members is implicated in both cancer initiation and progression.
  • Circular RNAs (circRNAs) are emerging as significant molecules in cancer, with potential as diagnostic biomarkers and therapeutic targets.

Purpose of the Study:

  • To review the roles of the EIF4 family in cancer.
  • To explore the complex interplay between circRNAs and EIF4s.
  • To discuss the potential of circRNA-based therapeutics targeting EIF4s in cancer research.

Main Methods:

  • Literature review of emerging studies on EIF4 family in cancer.
  • Analysis of molecular pathways governing circRNA-EIF4 interactions.
  • Evaluation of circRNA-based therapeutic strategies targeting EIF4s.

Main Results:

  • EIF4 family members are significantly dysregulated in various cancers.
  • EIF4s influence circRNA biogenesis, transport, and function.
  • CircRNAs can modulate EIF4 expression through specific molecular mechanisms.

Conclusions:

  • The intricate relationship between circRNAs and EIF4s presents novel avenues for cancer diagnosis and treatment.
  • Targeting EIF4s with circRNA-based therapeutics holds promise for clinical cancer research.
  • Further investigation into circRNA-EIF4 interactions is warranted for developing effective cancer therapies.
Keywords:
Cancer therapyCircular RNAEIF4 familyInterplay

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.6K
Identification of Circular RNAs using RNA Sequencing08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.3K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.1K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K