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Updated: Jul 25, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Elucidating causative gene variants in hereditary Parkinson's disease in the Global Parkinson's Genetics Program
Lara M Lange1, Micol Avenali2,3, Melina Ellis4,5
1Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Abstract:
The Monogenic Network of the Global Parkinson's Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of novel genetic causes of Parkinson's disease (PD) and to improve our understanding of already identified genetic causes, such as reduced penetrance and variable clinical expressivity of known disease-causing variants. We aim to perform short- and long-read whole-genome sequencing for up to 10,000 patients with parkinsonism. Important features of this project are global involvement and focusing on historically underrepresented populations.
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