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Updated: Jul 25, 2025

A Tissue Clearing Method for Neuronal Imaging from Mesoscopic to Microscopic Scales
Published on: May 10, 2022
Unlocking the secrets of the invisible world: incredible deep optical imaging through in-silico clearing
Ting-Hui Xiao1,2,3, Yuqi Zhou3, Keisuke Goda4,5,6
1Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou, 450052, China.
Abstract:
In-silico clearing enables deep optical imaging of biological samples by correcting image blur caused by scattering and aberration. This breakthrough method offers researchers unprecedented insights into three-dimensional biological systems, with enormous potential for advancing biology and medicine to better understand living organisms and human health.
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