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Self-reported treatment effectiveness for Crohn's disease using a novel crowdsourcing web-based platform
Tal Engel1,2, Eran Dotan2,3, Yossi Synett3
1Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.
United European Gastroenterology Journal
|June 28, 2023
Summary
This study found Infliximab to be the most effective treatment for Crohn's disease based on patient-reported outcomes from an AI-powered online platform. The platform helps patients and doctors choose the best therapies for managing Crohn's disease.
Area of Science:
- Digital Health
- Artificial Intelligence in Medicine
- Patient-Reported Outcomes
Background:
- Internet platforms enable collection of patient experience data for chronic conditions.
- StuffThatWorks (STW) is an AI and crowdsourcing platform for patients with chronic diseases.
- This study focuses on patient-reported outcomes in Crohn's disease.
Purpose of the Study:
- To conduct an international, AI-driven, crowdsourced study on patient-reported treatment effectiveness in Crohn's disease.
- To analyze and rank the effectiveness of various treatments for Crohn's disease using real-world patient data.
- To evaluate the utility of online platforms for collecting and analyzing patient-reported outcomes.
Main Methods:
- A proprietary STW Bayesian inference model was used to assess treatment effectiveness.
- Effectiveness was measured on a 1-5 scale for Crohn's disease severity.
- Multiple comparisons and odds ratios were calculated for first-line biological treatments.
Main Results:
- 7593 patients with Crohn's disease were included in the analysis.
- Infliximab was ranked the most effective treatment, followed by bowel surgery, adalimumab, ustekinumab, and vedolizumab.
- Infliximab, adalimumab, and ustekinumab showed higher effectiveness compared to vedolizumab.
Conclusions:
- This is the first crowdsourcing AI platform study on self-reported treatment effectiveness in Crohn's disease.
- Online patient-reported outcome platforms can aid clinicians and patients in treatment selection.
- Crowdsourced data provides valuable insights into real-world treatment effectiveness for chronic conditions.
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