Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

84
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
84
Factors Affecting Drug Distribution: Miscellaneous Factors01:19

Factors Affecting Drug Distribution: Miscellaneous Factors

399
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
399
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

211
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
211
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

185
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
185

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum Isolevuglandin IgG Antibody Concentrations Are Increased in Patients with Systemic Lupus Erythematosus and Associated with Lower 24-Hour Blood Pressure.

Frontiers in lupus·2026
Same author

Vaccination attitudes and intentions reported by Canadian children and their parents in the CHILD Cohort Study during the COVID-19 pandemic.

BMC public health·2026
Same author

Climacteric symptoms among full-time working HRT never-users in different work environments: a cross-sectional study.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2026
Same author

Appropriateness and determinants of outpatient antibiotic use among migrants in British Columbia, Canada: a population-based study.

JAC-antimicrobial resistance·2026
Same author

Breastfeeding may lessen socioeconomic disparities in child health through differences in the infant gut microbiome.

Cell reports. Medicine·2026
Same author

The Bright Side of Life: Optimism and Risk of Dementia.

Journal of the American Geriatrics Society·2026

Related Experiment Video

Updated: Jul 25, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.0K

Do Patients' Psychosocial Characteristics Impact Antibiotic Prescription Rates?

Säde Stenlund1,2,3,4, Louise C Mâsse1,5, David Stenlund6,7

  • 1School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Antibiotics (Basel, Switzerland)
|June 28, 2023
PubMed
Summary

Patient psychosocial factors like stress and optimism do not directly increase antibiotic prescriptions. Poor health and frequent healthcare use, however, are linked to higher antibiotic prescribing rates.

Keywords:
antibiotic consumptionantibiotic prescribingantimicrobial stewardshipexcess antibiotic usepsychosocialstructural equation modeling

More Related Videos

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.4K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

6.6K

Related Experiment Videos

Last Updated: Jul 25, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.0K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.4K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

6.6K

Area of Science:

  • Public Health
  • Health Services Research
  • Psychology

Background:

  • Antibiotic overuse is a significant public health concern.
  • Patient and physician factors influence antibiotic prescribing.
  • The role of patients' psychosocial characteristics in antibiotic overuse remains underexplored.

Purpose of the Study:

  • To investigate the association between patients' psychosocial characteristics and subsequent antibiotic prescriptions.
  • To explore the mediating roles of general health status and healthcare utilization.

Main Methods:

  • Analysis of survey data on psychosocial characteristics (life satisfaction, sense of coherence, stress, hostility, optimism) from 19,300 working-aged Finns (2003).
  • Linking survey data with Finnish national registry data on antibiotic prescriptions (2004-2006).
  • Utilized structural equation modeling and mediation analysis.

Main Results:

  • Adverse psychosocial characteristics were not directly associated with increased antibiotic prescriptions.
  • Psychosocial factors were strongly linked to poorer general health status.
  • Poorer general health and higher healthcare service utilization were associated with more antibiotic prescriptions.
  • Healthcare utilization mediated the relationship between psychosocial factors and antibiotic use.

Conclusions:

  • Patients' adverse psychosocial characteristics do not directly drive increased antibiotic prescribing.
  • Physicians should consider general health status and healthcare utilization patterns when prescribing antibiotics.
  • Findings encourage physicians to engage in active discussions about treatment options with patients.