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Updated: Jul 25, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Liquid Biopsy: Current Status and Future Perspectives.

Vesselin Baev¹, Danijela Koppers-Lalic², Bruno Costa-Silva³

¹Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria.

|June 28, 2023

Summary

This summary is machine-generated.

Biofluid analysis is crucial for cancer diagnosis and monitoring. Biomarker discovery in bodily fluids aids in understanding and managing oncological conditions effectively.

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Last Updated: Jul 25, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

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Published on: September 16, 2022

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

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Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

Area of Science:

Oncology
Biochemistry
Medical Diagnostics

Background:

The historical analysis of biofluids for cancer detection dates back to the Bence Jones protein discovery in the 19th century.
Key protein biomarkers like carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) were identified in the 1970s, highlighting biofluid utility.
Modern advancements continue to leverage biofluid analysis for cancer management.

Discussion:

Biofluid analysis provides a minimally invasive approach to cancer detection and monitoring.
Biomarkers in biofluids offer insights into tumor presence, progression, and treatment response.
The evolution of analytical techniques enhances the sensitivity and specificity of cancer biomarker detection.

Key Insights:

The long-standing role of biofluid analysis in oncology underscores its diagnostic significance.
Identification of specific biomarkers like CEA and AFP revolutionized cancer follow-up.
Ongoing research focuses on novel biofluid biomarkers for earlier and more accurate cancer diagnosis.

Outlook:

Future directions include the development of multi-analyte panels for comprehensive cancer profiling.
Liquid biopsy technologies are poised to transform cancer diagnostics and personalized medicine.
The integration of artificial intelligence with biofluid analysis will accelerate biomarker discovery and clinical application.