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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Targeted Therapies and Developing Precision Medicine in Gastric Cancer

Rille Pihlak1, Caroline Fong1, Naureen Starling1

  • 1Gastrointestinal/Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.

Cancers
|June 28, 2023
PubMed

Insights

Gastric cancer survival remains poor, but new targeted treatments and predictive biomarkers show promise. Precision medicine offers hope for improved outcomes in advanced stages.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Gastric cancer has a poor prognosis, especially in advanced stages.
  • Current targeted treatments are limited to HER2, MSI, and PD-L1 status.
  • Despite advances, effective treatment strategies for many patients are lacking.

Purpose of the Study:

  • To review predictive biomarkers for gastric cancer.
  • To summarize novel targeted treatments under investigation.
  • To explore reasons for conflicting clinical trial results and future directions in precision medicine.

Main Methods:

  • Literature review of previous and ongoing studies.
  • Analysis of predictive biomarkers and targeted therapies.
  • Discussion of clinical trial outcomes and challenges.

Main Results:

  • HER2, MSI, and PD-L1 are established predictive biomarkers.
  • Emerging biomarkers and targeted agents show potential for improved survival.
  • Conflicting trial results highlight the complexity of gastric cancer treatment.

Conclusions:

  • Precision medicine holds significant promise for advancing gastric cancer care.
  • Further research into novel biomarkers and treatments is crucial.
  • Personalized therapeutic strategies are key to improving patient outcomes.
Keywords:
FGFRGLDN18.2HER2gastric cancerimmunotherapyprecision medicine

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