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Updated: Jul 25, 2025

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Functional PET Neuroimaging in Consciousness Evaluation: Study Protocol.

Tom Paunet¹, Denis Mariano-Goulart¹, Jeremy Deverdun²

¹Department of Nuclear Medicine, Gui de Chauliac Hospital, Montpellier University Hospital Center, University of Montpellier, 34090 Montpellier, France.

Diagnostics (Basel, Switzerland)

|June 28, 2023

Summary

This summary is machine-generated.

Functional PET (fPET) neuroimaging can predict coma recovery. This study uses fPET to measure brain metabolism changes in comatose patients, aiming to forecast neurological outcomes at 18 months.

Keywords:

18F-FDG PET coma constant infusion disorder of consciousness dynamic PET fPET functional PET glucose metabolism stimuli

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Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[¹⁸F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

Area of Science:

Neuroscience
Medical Imaging
Metabolism

Background:

Evaluating coma depth and predicting neurological outcomes is challenging.
Positron Emission Tomography (PET) neuroimaging offers a potential diagnostic and prognostic tool for comatose patients.
Functional PET (fPET) allows for quantifying task-specific neuronal metabolism changes in a single session.

Purpose of the Study:

To determine if task-specific changes in glucose metabolism during the acute phase of coma can predict neurological recovery at 18 months.
To evaluate global cerebral metabolism in comatose patients using a modified PET-CT protocol.
To investigate the relationship between brain activation patterns during auditory stimulation and coma recovery.

Main Methods:

A modified PET-CT protocol involving 18F-fluorodeoxyglucose (18F-FDG) bolus plus continuous infusion and dynamic acquisition.
A 55-minute fPET session with a 20% bolus + 80% infusion protocol.
Two blocks of auditory and emotional auditory stimulation, with regional brain metabolism compared at rest and during stimulation.
Activation analysis using custom Python software and multivariate analysis to correlate activation levels with the Coma Recovery Scale-Revisited (CRS-R).

Main Results:

Emotional auditory stimulation is expected to activate auditory cortex, consciousness areas, and emotion-related neural circuitry.
Regional brain metabolism patterns during stimulation will be compared to baseline.
The association between activation levels and coma recovery at 18 months will be assessed.

Conclusions:

This study aims to improve coma prognosis by analyzing neuronal metabolism patterns in the acute phase.
Successful implementation of fPET could provide a more robust method for evaluating coma depth and predicting neurological outcomes.
Findings will contribute to a better understanding of brain function in comatose states and recovery prediction.