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Related Concept Videos

Acute Kidney Injury I: Introduction01:22

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Acute Kidney Injury II: Pathophysiology01:29

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury III: Clinical Manifestations01:29

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Nephrotic Syndrome I : Introduction01:24

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Related Experiment Video

Updated: Jul 25, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

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Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus?

Tuba Taslamacioglu Duman1, Feyza Nihal Ozkul1, Buse Balci1

  • 1Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey.

Diagnostics (Basel, Switzerland)
|June 28, 2023
PubMed
Summary

The systemic inflammatory index (SII) can help detect diabetic kidney injury (DKI) in diabetes patients. Higher SII values are linked to increased risk, making it a potential diagnostic tool.

Keywords:
diabetic kidney injuryinflammationsystemic inflammatory index

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Area of Science:

  • Nephrology
  • Inflammation Research
  • Diabetology

Background:

  • The systemic inflammatory index (SII) is an emerging marker for chronic inflammatory conditions.
  • Diabetic nephropathy (DKI) is a significant complication of diabetes, characterized by chronic inflammation.
  • The relationship between SII and the presence and severity of DKI requires further investigation.

Purpose of the Study:

  • To investigate the association between the systemic inflammatory index (SII) and diabetic nephropathy (DKI) in diabetic patients.
  • To evaluate the diagnostic potential of SII in identifying DKI.
  • To compare SII levels across diabetic patients with and without DKI, and healthy controls.

Main Methods:

  • A comparative study design was employed, including diabetic patients with and without DKI, and a healthy control group.
  • Patients were recruited from an outpatient clinic.
  • Systemic inflammatory index (SII) values and other clinical parameters were collected and compared among the three groups.

Main Results:

  • Median SII was significantly higher in patients with DKI (584) compared to those without (282) and controls (236) (p < 0.001).
  • SII showed positive correlations with BMI, weight, blood glucose, HbA1c, CRP, and creatinine, and a negative correlation with GFR.
  • An SII threshold of 336 demonstrated 75% sensitivity and 70% specificity for detecting DKI.

Conclusions:

  • The systemic inflammatory index (SII) is a potential predictor of diabetic kidney injury (DKI).
  • SII can serve as an adjunctive diagnostic marker for DKI in diabetic individuals.
  • Further research can explore the utility of SII in monitoring disease progression and treatment response.