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Related Concept Videos

Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammation01:38

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
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Metabolic Inflammation and Cellular Immunity.

Sardar Sindhu1, Rasheed Ahmad2

  • 1Animal & Imaging Core Facility, Dasman Diabetes Institute, Dasman 15462, Kuwait.

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|June 28, 2023
PubMed
Summary

Metabolic and immune cell functions are closely connected and influence each other. Understanding this interplay is crucial for developing new therapies targeting metabolic and immune disorders.

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Area of Science:

  • Immunometabolism
  • Cellular Metabolism
  • Immune Cell Biology

Background:

  • Metabolic processes within immune cells significantly impact their function and differentiation.
  • Immune responses can alter the metabolic landscape of various tissues.

Discussion:

  • The intricate relationship between cellular metabolism and immune cell activity is bidirectional.
  • Metabolic pathways are key regulators of immune cell activation, proliferation, and effector functions.

Key Insights:

  • Specific metabolic pathways, such as glycolysis and oxidative phosphorylation, are critical for T cell-mediated immunity.
  • Metabolic reprogramming is essential for macrophage polarization and their subsequent roles in inflammation and tissue repair.

Outlook:

  • Targeting metabolic pathways in immune cells offers a promising therapeutic strategy for inflammatory and autoimmune diseases.
  • Further research into immunometabolism will illuminate novel approaches for cancer immunotherapy and infectious disease treatment.