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Updated: Jul 25, 2025

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Pathophysiological Roles of the TRPV4 Channel in the Heart

Sébastien Chaigne1,2,3, Solène Barbeau2, Thomas Ducret2

  • 1IHU LIRYC Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, 33600 Bordeaux, France.

Cells
|June 28, 2023
PubMed

Insights

The transient receptor potential vanilloid 4 (TRPV4) channel plays key roles in heart cell functions and cardiovascular diseases. Understanding TRPV4

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Cellular Signaling

Background:

  • The transient receptor potential vanilloid 4 (TRPV4) channel is a calcium-permeable cation channel involved in intracellular calcium handling.
  • TRPV4 is broadly expressed, including in cardiomyocytes, endothelial cells, and smooth muscle cells, influencing various physiological processes.
  • Dysregulation of TRPV4 is implicated in numerous cardiovascular pathologies.

Purpose of the Study:

  • To provide a comprehensive overview of TRPV4 channel functions in cardiac physiology.
  • To explore the role of TRPV4 in cardiovascular diseases.
  • To discuss the therapeutic potential of targeting TRPV4 for cardiovascular conditions.

Main Methods:

  • Literature review of studies on TRPV4 expression and function in the cardiovascular system.
  • Analysis of TRPV4 involvement in both normal cardiac function and pathological states.
  • Synthesis of current research on TRPV4 as a therapeutic target.

Main Results:

  • TRPV4 modulates mitochondrial activity, calcium homeostasis, cardiomyocyte electrical activity, and contractility.
  • TRPV4 influences vascular tone, permeability, and cardiac development.
  • TRPV4 channels are implicated in cardiac fibrosis, hypertrophy, ischemia-reperfusion injury, heart failure, myocardial infarction, and arrhythmia.

Conclusions:

  • TRPV4 channels are critical regulators of cardiac physiology and pathophysiology.
  • Targeting TRPV4 presents a promising therapeutic strategy for managing cardiovascular diseases.
  • Further research into TRPV4 modulation could lead to novel treatments for heart conditions.
Keywords:
TRPV4 channelsTRPV4-KO miceaction potentialcalcium homeostasisendothelial cellsfibroblastsheartmyocytes

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