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MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges?

Han Yang1,2, Yufang Liu1,2, Longqing Chen1,2

  • 1Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China.

Biomolecules
|June 28, 2023
PubMed

Insights

MicroRNAs (miRNAs) show promise in treating lung cancer, complementing existing therapies and reversing drug resistance. miRNA-based treatments are advancing into clinical trials for improved lung cancer patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer is a leading cause of cancer deaths globally.
  • Advanced lung cancer prognosis remains poor despite recent therapeutic advancements.
  • MicroRNAs (miRNAs) play a crucial role in regulating tumor development.

Purpose of the Study:

  • To review recent advances in microRNA (miRNA)-based therapies for lung cancer.
  • To discuss the current state of clinical lung cancer treatment.
  • To explore the potential of miRNA-based therapies as adjuvant treatments and to overcome drug resistance.

Main Methods:

  • Review of current literature on miRNA-based therapies in lung cancer.
  • Analysis of preclinical and clinical trial data for miRNA and small interfering RNA (siRNA) therapies.
  • Discussion of challenges and future directions for miRNA-based lung cancer treatment.

Main Results:

  • miRNA mimics and regulatory molecules show preclinical promise.
  • miRNA-based therapies can enhance conventional treatments, reversing drug resistance.
  • Small interfering RNA (siRNA) and miRNA therapies are progressing favorably in clinical trials.

Conclusions:

  • miRNA-based therapies offer a promising avenue for lung cancer treatment and adjuvant therapy.
  • These therapies have the potential to improve sensitivity and overcome resistance in lung cancer cells.
  • Further research and clinical application are needed to address challenges and develop novel lung cancer therapies.
Keywords:
MiRNA-based therapychemoradiotherapyimmunotherapylung cancermicroRNAstargeted therapy

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