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Updated: Jul 25, 2025

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
The Effects of a High-Fat Diet on Inflammatory Bowel Disease
Yuan Dang1,2,3, Chunxiang Ma1,2,3, Kexin Chen1,2,3
1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract:
The interactions among diet, intestinal immunity, and microbiota are complex and play contradictory roles in inflammatory bowel disease (IBD). An increasing number of studies has shed light on this field. The intestinal immune balance is disrupted by a high-fat diet (HFD) in several ways, such as impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. In contrast, a rational diet is thought to maintain intestinal immunity by regulating gut microbiota. In this review, we emphasize the crucial contributions made by an HFD to the gut immune system and microbiota.
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