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Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review

Federica Piani1,2, Giovanni Tossetta3, Gabriel Cara-Fuentes4

  • 1Cardiovascular Internal Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Biomolecules
|June 28, 2023
PubMed

Insights

Cluster of Differentiation (CD) 93 is linked to cardiovascular disease (CVD) risk factors and conditions. Further research is needed to confirm CD93

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Molecular Biology

Background:

  • Cluster of Differentiation (CD) 93, also known as complement protein 1 q subcomponent receptor (C1qR1), is a transmembrane glycoprotein with soluble forms (sCD93).
  • Emerging research suggests a role for CD93 in the pathogenesis of cardiovascular disease (CVD).

Approach:

  • A systematic review was conducted, searching PubMed, EMBASE, and Web of Science databases up to February 2023.
  • Included human studies investigated associations between CD93 (protein levels or genetic polymorphisms) and cardiovascular risk factors or CVD outcomes.
  • Data collection and analysis were performed by two independent reviewers.

Key Points:

  • Fifteen studies were included, examining CD93's association with hypertension, dyslipidemia, obesity, heart failure, coronary artery disease, and ischemic stroke.
  • The review assessed CD93 at both proteomic and genomic levels.
  • Current evidence suggests potential links between CD93 and cardiovascular health.

Conclusions:

  • While promising, the existing studies are limited in quality and scope.
  • Definitive conclusions regarding the diagnostic or prognostic value of CD93 in CVD cannot be drawn yet.
  • Further high-quality research is warranted to elucidate the role of CD93 in cardiovascular medicine.
Abstract

Keywords:
C1qR1C1qRpCD93cardiovascular diseasecardiovascular mortalitycardiovascular outcomescardiovascular risk factorscomplement protein 1 q subcomponent receptor

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