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Related Experiment Video

Updated: Jul 25, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Senopathies-Diseases Associated with Cellular Senescence.

Oleh Lushchak1,2,3, Markus Schosserer4,5, Johannes Grillari1,5,6

  • 1Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1200 Vienna, Austria.

Biomolecules
|June 28, 2023
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a state of cell cycle arrest, contributes to aging and disease. Targeting these senescent cells offers a promising therapeutic strategy for various "senopathies".

Keywords:
age-related diseaseagingcellular senescencegerosciencepathologysenescence-associated secretory phenotype (SASP)senolyticsenomorphicsenopathysenotherapy

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Area of Science:

  • Gerontology and Cellular Biology
  • Pathology and Disease Mechanisms

Background:

  • Cellular senescence is a stable cell cycle arrest state with a distinct phenotype.
  • Accumulation of senescent cells in the body during aging contributes to age-related diseases and pathologies.
  • These senescent cells play a role in aging and various diseases, impacting lifespan and health.

Purpose of the Study:

  • To introduce the term "senopathies" for diseases associated with cellular senescence.
  • To highlight the therapeutic potential of targeting senescent cells (senolytics and senomorphics) for disease mitigation.
  • To underscore the challenges in senotherapy development due to senescence heterogeneity.

Main Methods:

  • Review of existing literature on cellular senescence and its role in disease.
  • Identification and categorization of diseases linked to senescent cell accumulation.
  • Analysis of evidence from animal studies demonstrating the connection between senescent cells and disease progression.

Main Results:

  • Cellular senescence is implicated in a wide range of pathologies, including cardiovascular, metabolic, musculoskeletal, liver, kidney, lung diseases, and neurodegeneration.
  • Animal studies provide strong mechanistic evidence linking senescent cell accumulation to disease progression.
  • The heterogeneity of senescence phenotypes presents a significant challenge for developing universal biomarkers and effective senotherapies.

Conclusions:

  • Cellular senescence is a key driver in the pathogenesis and progression of numerous diseases, now termed "senopathies".
  • Targeting senescent cells holds significant therapeutic promise for mitigating a broad spectrum of age-related and other pathologies.
  • Overcoming the heterogeneity of senescence is crucial for advancing senotherapies and developing effective treatments.