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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

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Published on: August 13, 2017

Synuclein Proteins in Cancer Development and Progression.

Lucía C Zanotti^1,2,3,4, Florencia Malizia^1,2,3,4, Nahuel Cesatti Laluce^1,2,3,4

¹Instituto de Inmunología Clínica y Experimental de Rosario (IDICER, CONICET-UNR), Facultad de Ciencias Médicas (UNR), Rosario 3100, Argentina.

|June 28, 2023

Summary

This summary is machine-generated.

Synucleins, proteins linked to neurodegeneration, are also implicated in cancer development. This review explores their role in tumors and potential use as cancer biomarkers.

Keywords:

aggregation biomarkers cancer pathways synucleins

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Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

Area of Science:

Molecular Biology
Oncology
Neuroscience

Background:

Synucleins are small, soluble proteins predominantly found in neural tissue.
These proteins are extensively studied due to their association with severe human diseases, including neurodegenerative disorders and cancer.
The precise physiological functions of synucleins remain largely unknown.

Purpose of the Study:

To review and synthesize current knowledge on the connection between synucleins and cancer.
To describe the structural characteristics of synucleins relevant to their oncogenic roles.
To discuss the potential of synucleins as molecular biomarkers for cancer diagnosis and prognosis.

Main Methods:

Literature review of scientific reports on synucleins and cancer.
Analysis of structural data of synuclein proteins.
Examination of studies investigating synuclein involvement in tumor-related processes.

Main Results:

Synucleins are expressed in various tumor types.
Evidence suggests synucleins participate in key cancer-related cellular mechanisms.
The structural features of synucleins may contribute to their oncogenic functions.

Conclusions:

Synucleins play a significant role in cancer biology.
Synucleins hold promise as potential biomarkers for cancer detection and monitoring.
Further research is warranted to fully elucidate the therapeutic and diagnostic potential of synucleins in oncology.