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Matrix Metalloproteinases in Oral Health-Special Attention on MMP-8

Tsvetelina Atanasova1, Teodora Stankova2, Anelia Bivolarska2

  • 1Faculty of Dental Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.

Biomedicines
|June 28, 2023
PubMed

Insights

Matrix metalloproteinases (MMPs) are crucial for oral health. This review highlights MMP-8

Area of Science:

  • Biochemistry
  • Oral Biology
  • Enzymology

Background:

  • Matrix metalloproteinases (MMPs) are Ca2+ and Zn2+-dependent proteolytic enzymes.
  • MMPs and their inhibitors (TIMPs) play key roles in oral health, tooth development, and enamel maturation.

Purpose of the Study:

  • To summarize the functions of MMPs, focusing on MMP-8.
  • To review the role of MMP-8 in periodontitis, peri-implantitis, and carious lesions.
  • To emphasize the role of MMP8 gene variants in oral disease predisposition.

Main Methods:

  • Literature review and synthesis of existing research findings.

Main Results:

  • MMP-8 is implicated in the development and progression of periodontitis, peri-implantitis, and carious lesions.
  • Specific gene variants in MMP8 are associated with increased susceptibility to certain oral diseases.

Conclusions:

  • MMP-8 is a significant factor in the pathogenesis of common oral diseases.
  • Genetic predisposition related to MMP8 variants contributes to oral disease risk.
Keywords:
MMP-8cariesimplant lossmatrix metalloproteinaseperi-implantitisperiodontitis

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