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Physiological Activity of Trace Element Germanium including Anticancer Properties.

Leonid G Menchikov¹, Anatoliy V Popov²

¹N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prosp. 47, 119991 Moscow, Russia.

|June 28, 2023

Summary

Germanium compounds show promise as anticancer agents, with recent research clarifying their toxicity and biological activity. This review addresses historical inaccuracies and explores their potential in combating oxidative stress and cancer.

Keywords:

Ge-132 Warburg effect biological activity cancer germanium compounds germatrane

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Area of Science:

Medicinal Chemistry
Biochemistry
Oncology

Background:

Germanium is an essential microelement linked to disease prevention, especially cancer.
Water-soluble germanium compounds exhibit significant biological activity, warranting further investigation.
Previous research on germanium's biological effects has been hampered by misconceptions and suppressed historical data.

Purpose of the Study:

To review recent research on the anticancer properties of germanium compounds.
To clarify the toxicity and biological activity of these compounds.
To correct historical distortions regarding water-soluble organic germanium compounds.

Main Methods:

Comprehensive literature review of primary research from the past decade.
Analysis of studies on germanium compound toxicity and biological effects.
Historical research into the discovery and dissemination of information on organic germanium compounds.

Main Results:

Recent research supports the anticancer potential of various germanium compounds.
Clarification of actual toxicity profiles, debunking previous misconceptions.
Identification of a potential mechanism for germanium-mediated protection against oxidative stress.

Conclusions:

Water-soluble germanium compounds possess notable anticancer activity.
Addressing historical inaccuracies is crucial for understanding their therapeutic potential.
Further research into germanium's role in mitigating oxidative stress and cancer is warranted.