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Serum Asprosin Correlates with Indirect Insulin Resistance Indices
Małgorzata Mirr1,2, Anna Braszak-Cymerman3, Aleksandra Ludziejewska4
1Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806 Poznań, Poland.
Biomedicines
|June 28, 2023
Summary
Serum asprosin levels are significantly higher in individuals with obesity and correlate strongly with insulin resistance markers. Asprosin shows potential as a reliable indicator for both obesity and insulin resistance.
Area of Science:
- Endocrinology
- Metabolic Health
- Biochemistry
Background:
- Insulin resistance is a key factor in type 2 diabetes development.
- Asprosin, a novel adipokine, is implicated in glycemic regulation.
- Non-invasive tests can provide indirect indicators of insulin resistance.
Purpose of the Study:
- To investigate the correlation between serum asprosin levels and various insulin resistance indices.
- To examine the relationship between circulating asprosin and obesity indices.
Main Methods:
- Study included 50 non-diabetic obese patients and 50 healthy volunteers.
- Collected laboratory and anthropometric data, including serum asprosin.
- Calculated multiple insulin resistance indices (e.g., TyG, TyG-BMI, TG/HDLc).
Main Results:
- Obese patients exhibited significantly higher asprosin concentrations (p < 0.001).
- Asprosin positively correlated with BMI, waist circumference, and all tested insulin resistance indices.
- The strongest correlation was found between asprosin and the triglyceride-glucose index to body mass index (TyG-BMI).
Conclusions:
- Asprosin concentrations are elevated in obesity.
- Serum asprosin levels demonstrate a strong association with insulin resistance markers.
- Asprosin can be considered a potential biomarker for both obesity and insulin resistance.
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