Current State and Prospectives for Proton Boron Capture Therapy.

Area of Science:

• Radiation Oncology
• Nuclear Medicine
• Medical Physics

Background:

• Proton therapy (PT) is a key radiation oncology treatment.
• Enhancing PT's biological effectiveness is crucial for improved patient outcomes.
• Binary technologies, combining radiation with radiosensitizers, offer a promising strategy.

Purpose of the Study:

• To review the effectiveness and prospects of proton boron capture therapy (PBCT).
• To explore PBCT as a binary technology for enhancing radiation therapy.
• To summarize theoretical and experimental data on PBCT's potential.

Main Methods:

• Review of theoretical studies on PBCT.
• Analysis of experimental data on PBCT effectiveness.
• Focus on proton capture reactions with Boron-11 (¹¹B).

Main Results:

• PBCT utilizes the ¹¹B(p,α)⁸Be reaction to increase absorbed dose in tumors.
• The selective accumulation of radiosensitizers enhances proton radiation's damaging effect.
• PBCT shows potential for significantly increasing radiation therapy effectiveness.

Conclusions:

• Proton boron capture therapy (PBCT) presents a viable approach to enhance proton therapy.
• Further research and experimental validation are essential to realize PBCT's full potential.
• PBCT offers a promising avenue for more effective cancer treatment.