Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Structure-Activity Relationship Analysis and hERG Liability Assessment of Second-Generation Antibiofilm Compounds Active Against Salmonella.

ChemMedChem·2026

Same author

Metacycloprodigiosin produced by a high-yield <i>Streptomyces spectabilis</i> restores colistin susceptibility in resistant Gram-negative pathogens.

Organic & biomolecular chemistry·2026

Same author

All About That Base: Dietary Plasticity, Basicranial Flexion and Sphenoid Form.

American journal of biological anthropology·2026

Same author

IMD-0354 optimization generates potent colistin adjuvants with in vivo activity and reduced eukaryotic toxicity.

European journal of medicinal chemistry·2026

Same author

Evaluating the utility of a nanoscale flow cytometer for detection of surface proteins on HIV and extracellular vesicles.

Virology journal·2026

Same author

Growth-Inhibitory Activity of a Clerodane Diterpene from <i>Callicarpa americana</i> Leaf Extracts and Its Derivatives against <i>Cutibacterium acnes</i>.

ACS infectious diseases·2026

Search research articles

Related Experiment Video

Updated: Jul 25, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot

Elizabeth I Harper^1,2,3, Michael D Siroky^2,3, Tyvette S Hilliard^2,3

¹Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN 46556, USA.

International Journal of Molecular Sciences

|June 28, 2023

Summary

Advanced glycation end products (AGEs) contribute to ovarian cancer progression in older women. This study explores AGE breakers, showing their potential to alter the tumor microenvironment and improve treatment response.

Keywords:

AGE breakers ALT-711 Alagebrium advanced glycation end product (AGE)collagen microenvironment omentum ovarian cancer

More Related Videos

A Proximal Culture Method to Study Paracrine Signaling Between Cells

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jul 25, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

A Proximal Culture Method to Study Paracrine Signaling Between Cells

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

Published on: January 26, 2024

Area of Science:

Oncology
Gerontology
Biochemistry

Background:

Ovarian cancer is a leading cause of cancer death in women, particularly those over 60.
Age-related changes in the tumor microenvironment, such as advanced glycation end products (AGEs) crosslinking collagen, promote metastasis.
The therapeutic potential of AGE breakers in ovarian cancer remains unexplored.

Purpose of the Study:

To investigate the efficacy of AGE breakers in targeting age-related changes in the ovarian cancer microenvironment.
To assess the potential of AGE breakers to improve treatment response in older ovarian cancer patients.

Main Methods:

Pilot study evaluating AGE breakers.
Analysis of changes in omental collagen structure.
Modulation of the peritoneal immune landscape.

Main Results:

AGE breakers demonstrated the potential to alter omental collagen structure.
AGE breakers showed capacity to modulate the peritoneal immune landscape.

Conclusions:

AGE breakers may represent a novel therapeutic strategy for ovarian cancer.
Targeting AGEs could improve treatment outcomes for older ovarian cancer patients.