Related Experiment Video

Updated: Jul 25, 2025

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
06:49

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

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Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date

Konstantinos Valtetsiotis1, Georgios Valsamakis1, Evangelia Charmandari1

  • 1Second Department of Obstetrics and Gynaecology, Aretaieion University Hospital, National and Kapodistrian University of Athens Medical School, 115 28 Athens, Greece.

International Journal of Molecular Sciences
|June 28, 2023
PubMed

Insights

This review explores metabolic pathways in ovarian aging and potential treatments like stem cells and caloric restriction. Understanding these links may extend female fertility and reduce reliance on artificial reproductive techniques.

Area of Science:

  • Reproductive biology
  • Metabolic science
  • Gerontology

Background:

  • Female infertility and delayed childbearing are increasing healthcare concerns.
  • Ovarian aging significantly impacts female reproductive potential.

Purpose of the Study:

  • To review novel metabolic mechanisms underlying ovarian aging.
  • To explore emerging medical treatments for ovarian aging and female infertility.

Main Methods:

  • Literature review of recent data on metabolic pathways and ovarian aging.
  • Examination of experimental stem cell procedures.
  • Analysis of caloric restriction, hyperbaric oxygen treatment, and mitochondrial transfer.

Main Results:

  • Metabolic pathways are intricately linked to ovarian aging processes.
  • Several novel treatments show potential in preclinical or experimental stages.
  • Understanding these connections offers new avenues for intervention.

Conclusions:

  • Targeting metabolic mechanisms could prevent ovarian aging and prolong fertility.
  • Emerging therapies may expand the female fertility window.
  • This research could decrease the need for assisted reproductive technologies.
Keywords:
agingfertilitylongevityoocytesreproduction

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