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Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans
Amra Jujic1,2,3, João P P Vieira1,4, Hana Matuskova1,4,5
1Wallenberg Centre for Molecular Medicine, Lund University, 22100 Lund, Sweden.
International Journal of Molecular Sciences
|June 28, 2023
Summary
Plasma galectin-4 (Gal-4) is elevated in individuals with ischemic stroke. This study found higher Gal-4 levels in both human stroke patients and in mice following experimental stroke.
Area of Science:
- Biomedical Research
- Cardiovascular Science
- Neurology
Background:
- Plasma galectin-4 (Gal-4) is linked to diabetes and coronary artery disease.
- No prior studies have investigated the association between plasma Gal-4 and stroke.
- Understanding novel biomarkers for stroke risk is crucial.
Purpose of the Study:
- To investigate the association between plasma Gal-4 levels and prevalent ischemic stroke in humans.
- To examine the effect of experimental ischemic stroke on plasma Gal-4 levels in mice, including those on a high-fat diet (HFD).
Main Methods:
- Linear and logistic regression analyses were used to assess Gal-4 association with prevalent stroke in a population-based cohort.
- Experimental ischemic stroke was induced in mice fed a standard or HFD to measure plasma Gal-4 changes.
Main Results:
- Plasma Gal-4 levels were significantly higher in subjects with prevalent ischemic stroke.
- Plasma Gal-4 was independently associated with prevalent ischemic stroke (OR 1.52; 95% CI 1.01-2.30).
- Plasma Gal-4 levels increased after experimental stroke in both control and HFD-fed mice, irrespective of diet.
Conclusions:
- This study demonstrates elevated plasma Gal-4 levels in humans with ischemic stroke.
- Plasma Gal-4 levels increase following experimental stroke in mice.
- Plasma Gal-4 may represent a potential biomarker for ischemic stroke.
