Exploring the Inhibitory Effect of AgBiS₂ Nanoparticles on Influenza Viruses

Influenza viruses are respiratory pathogens that are major threats to human health. Due to the emergence of drug-resistant strains, the use of traditional anti-influenza drugs has been hindered. Therefore, the development of new antiviral drugs is critical. In this article, AgBiS₂ nanoparticles were synthesized at room temperature, using the bimetallic properties of the material itself to explore its inhibitory effect on the influenza virus. By comparing the synthesized Bi₂S₃ and Ag₂S nanoparticles, it is found that after adding the silver element, the synthesized AgBiS₂ nanoparticles have a significantly better inhibitory effect on influenza virus infection than Bi₂S₃ and Ag₂S nanoparticles. Recent studies have shown that the inhibitory effect of AgBiS₂ nanoparticles on the influenza virus mainly occurs in the stages of influenza virus-cell internalization and intracellular replication. In addition, it is found that AgBiS₂ nanoparticles also have prominent antiviral properties against α and β coronaviruses, indicating that AgBiS₂ nanoparticles have significant potential in inhibiting viral activity.