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Chronic Heat Stress Affects Bile Acid Profile and Gut Microbiota in Broilers
Yuting Zhang1, Huimin Chen1, Wei Cong1
1Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
International Journal of Molecular Sciences
|June 28, 2023
Summary
Chronic heat stress negatively impacts broiler growth by altering bile acid (BA) metabolism and gut microbiota. This study reveals specific BA changes and their correlation with microbial shifts in heat-stressed chickens.
Area of Science:
- Animal Science
- Physiology
- Microbiology
Background:
- Heat stress (HS) significantly impacts broiler growth and economic outcomes.
- Altered bile acid (BA) pools are linked to chronic HS, but mechanisms involving gut microbiota are unclear.
Purpose of the Study:
- To investigate the effects of chronic heat stress on bile acid metabolism and gut microbiota in broilers.
- To elucidate the relationship between bile acid alterations and gut microbial changes under heat stress conditions.
Main Methods:
- Broilers were subjected to chronic heat stress (36°C) or control conditions (24°C) for 14 days.
- Serum BA levels, hepatic gene expression (CYP8B1, BSEP), ileal FGF19 expression, and gut microbial composition were analyzed.
Main Results:
- Heat-stressed broilers showed decreased total BAs but increased cholic acid (CA), chenodeoxycholic acid (CDCA), and taurolithocholic acid (TLCA).
- Hepatic CYP8B1 and BSEP were upregulated, while ileal FGF19 decreased in HS broilers.
- Significant gut microbial composition changes occurred, with *Peptoniphilus* enrichment positively correlated with TLCA levels.
Conclusions:
- Chronic heat stress disrupts bile acid metabolism homeostasis in broilers.
- Alterations in bile acid profiles are closely associated with changes in gut microbiota composition under heat stress.
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