Related Experiment Video

Updated: Jul 25, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

4.5K

JAK/STAT as a Potential Therapeutic Target for Osteolytic Diseases

Mariely A Godoi1, Angelo C Camilli1, Karen G A Gonzales1

  • 1Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP, Araraquara 14801-385, Brazil.

International Journal of Molecular Sciences
|June 28, 2023
PubMed

Insights

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is crucial in inflammatory bone diseases. JAK inhibitors show promise in preventing tissue destruction in osteolytic conditions.

Area of Science:

  • Immunology
  • Cell Biology
  • Rheumatology

Background:

  • The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway mediates cytokine functions in inflammatory diseases.
  • Persistent activation of the JAK/STAT pathway is increasingly linked to inflammatory bone (osteolytic) diseases, though mechanisms require further elucidation.

Purpose of the Study:

  • To review the critical role of the JAK/STAT signaling pathway in inflammation-induced bone resorption.
  • To highlight the potential of JAK inhibitors in managing osteolytic diseases.

Main Methods:

  • Review of existing literature on the JAK/STAT pathway in inflammation and bone resorption.
  • Analysis of clinical studies and experimental models investigating JAK inhibitors in osteolytic diseases.

Main Results:

  • The JAK/STAT pathway is integral to the pathogenesis of inflammatory bone diseases.
  • JAK inhibitors are a significant area of research for preventing mineralized tissue destruction in osteolytic conditions.

Conclusions:

  • The JAK/STAT pathway is a key target for therapeutic intervention in inflammatory bone diseases.
  • Further research into JAK inhibitors is warranted for their application in osteolytic diseases.
Keywords:
JAK/STAT inhibitorJAK/STAT signaling pathwaycytokinesosteoblastsosteoclastsosteolysisosteolytic disease

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

24.3K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.7K

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.5K
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K