Target and Cell Therapy for Atherosclerosis and CVD

Area of Science:

• Biomedical Science
• Regenerative Medicine
• Cardiology

Background:

• Cardiovascular diseases (CVD), particularly atherosclerosis, are the primary global cause of mortality.
• Current CVD treatments often initiate after symptom manifestation, highlighting the need for early pathogenetic interventions.
• Cell therapy presents a promising strategy for addressing tissue damage in CVD pathogenesis.

Purpose of the Study:

• To review and summarize the primary targets for cell therapy in cardiovascular diseases (CVD).
• To specifically focus on cell therapy applications for atherosclerosis.
• To provide an overview based on a comprehensive literature analysis.

Main Methods:

• Systematic literature review of PubMed and Scopus databases.
• Analysis of research published up to May 2023.
• Identification and summarization of key cell therapy targets for CVD and atherosclerosis.

Main Results:

• Cell therapy is a rapidly developing and potentially highly effective treatment for atherosclerosis-related CVD.
• Identified various cell types and mechanisms as targets for therapeutic intervention.
• Highlighted existing limitations within current cell therapy approaches for CVD.

Conclusions:

• Cell therapy holds significant potential for early intervention in cardiovascular diseases, especially atherosclerosis.
• Further research is needed to overcome current limitations and optimize cell therapy strategies.
• This review consolidates current knowledge on cell therapy targets for improved CVD management.