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Harnessing the Potential of Non-Apoptotic Cell Death Processes in the Treatment of Drug-Resistant Melanoma

Linyinxue Dong1,2,3, Ceeane Paul Dagoc Vargas3, Xuechen Tian1,2,3

  • 1Wenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou 325060, China.

International Journal of Molecular Sciences
|June 28, 2023
PubMed

Insights

This review explores non-apoptotic cell death in melanoma, including pyroptosis, ferroptosis, necroptosis, and cuproptosis. Targeting these pathways offers a promising strategy for treating drug-resistant melanoma.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Melanoma is a malignant skin cancer known for treatment resistance.
  • Non-apoptotic cell death pathways (pyroptosis, ferroptosis, necroptosis, cuproptosis) are increasingly studied.
  • Understanding these pathways is crucial for developing new melanoma therapies.

Purpose of the Study:

  • To review mechanisms and signaling pathways of non-apoptotic cell death in melanoma.
  • To explore the interplay between apoptosis, autophagy, and non-apoptotic cell death.
  • To highlight therapeutic potential of targeting non-apoptotic cell death in drug-resistant melanoma.

Main Methods:

  • Literature review of recent experimental evidence.
  • Analysis of signaling pathways involved in various cell death modalities.
  • Synthesis of current research on non-apoptotic cell death in melanoma.

Main Results:

  • Non-apoptotic cell death pathways are critical in melanoma.
  • These pathways interact with apoptosis and autophagy.
  • Targeting non-apoptotic cell death shows promise against drug resistance.

Conclusions:

  • Non-apoptotic cell death represents a viable therapeutic avenue for melanoma.
  • Further research into these pathways can guide novel treatment strategies.
  • This review consolidates evidence for combating melanoma drug resistance.
Keywords:
anti-cancer therapydrug resistancemelanomanon-apoptotic cell death

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