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Protein Biomarkers in Chronic Kidney Disease in Children-What Do We Know So Far?

Agnieszka Rybi Szumińska1, Anna Wasilewska1, Monika Kamianowska1

  • 1Department of Peadiatrics and Nephrology, Medical University of Bialystok, Waszyngtona 17, 15-297 Bialystok, Poland.

Journal of Clinical Medicine
|June 28, 2023
PubMed

Insights

Identifying new protein biomarkers is crucial for early diagnosis and management of pediatric chronic kidney disease (CKD). This research explores novel biomarkers to improve prognostication and treatment monitoring for children with CKD.

Area of Science:

  • Pediatric Nephrology
  • Biomarker Discovery
  • Chronic Kidney Disease Research

Background:

  • Pediatric chronic kidney disease (CKD) poses significant public health challenges, leading to high morbidity and mortality.
  • Current diagnostic markers like serum creatinine and GFR have limitations for early and specific detection in children.
  • Existing protein biomarker studies primarily focus on adult populations, leaving a gap in pediatric research.

Purpose of the Study:

  • To review recent advancements in identifying protein biomarkers for pediatric CKD.
  • To explore new perspectives on utilizing protein biomarkers for CKD prognostication and treatment monitoring in children.
  • To identify potential therapeutic targets among novel protein biomarkers for pediatric kidney disease.

Main Methods:

  • Literature review of recent studies on CKD protein biomarkers.
  • Analysis of identified blood and urine protein biomarkers, with a focus on pediatric applicability.
  • Discussion of the potential clinical utility of novel biomarkers in managing pediatric CKD.

Main Results:

  • Several protein biomarkers have been identified in recent years, though many studies focused on adults.
  • There is a need for validated protein biomarkers specifically for early detection and prognosis in pediatric CKD.
  • Novel biomarkers show promise for improving the monitoring of treatment response and identifying therapeutic targets.

Conclusions:

  • Current CKD markers in children are limited, necessitating the development of better diagnostic tools.
  • Protein biomarkers hold significant potential for advancing the early detection, prognosis, and treatment of pediatric CKD.
  • Further research is essential to validate and implement these novel biomarkers in clinical practice for improved pediatric kidney health outcomes.

Keywords:
childrenchronic kidney diseaseend-stage kidney diseaseprotein biomarker

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