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Updated: Jul 25, 2025
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Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis
Blažen Marijić1,2,3, Filip Tudor2,3, Stefan Janik4
1Institute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria.
Journal of Personalized Medicine
|June 28, 2023
Summary
Recurrent laryngeal squamous cell carcinoma (LSCC) is less common and occurs earlier than secondary primary tumors (SPT). Long-term follow-up is crucial as approximately 25% of LSCC patients develop SPTs within 5-10 years.
Area of Science:
- Oncology
- Otorhinolaryngology
- Cancer Research
Background:
- Laryngeal squamous cell carcinoma (LSCC) is a significant health concern.
- Surgical treatment outcomes for LSCC require further investigation.
- Understanding long-term risks like recurrence and secondary primary tumors is vital for patient management.
Purpose of the Study:
- To analyze outcomes in surgically treated laryngeal squamous cell carcinoma (LSCC) patients.
- To develop a predictive nomogram for patient survival.
- To compare the timing of disease recurrence versus secondary primary tumor development.
Main Methods:
- A multicenter retrospective study involving 352 LSCC patients.
- Development of a novel nomogram incorporating age, T- and N-classification, and treatment details.
- Analysis of recurrence rates and secondary primary tumor (SPT) development.
Main Results:
- Recurrence was observed in 18.5% of patients, typically within 16.5 months.
- Secondary primary tumors (SPTs) developed in 25.9% of patients by 60 months.
- Lung cancers were the most common SPTs (8.2%), followed by other head and neck cancers (6.0%), with a longer latency for head and neck SPTs.
Conclusions:
- Recurrent LSCC is less frequent and occurs earlier than SPTs.
- Long-term surveillance, including imaging, is recommended due to the high incidence of SPTs (1 in 4 patients within 5-10 years).
- The developed nomogram demonstrated utility in survival estimation.
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