Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

104
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
104
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

763
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
763
Schizophrenia01:17

Schizophrenia

150
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
150
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

146
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
146
Human Genetics01:28

Human Genetics

625
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
625

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study.

European child & adolescent psychiatry·2026
Same author

Genetic susceptibility of cardiometabolic outcomes in schizophrenia spectrum disorders.

Schizophrenia research·2026
Same author

Financial competence, situation, and context of people with recent-onset psychosis: A comparison with matched controls and the role of cognition.

Neuropsychology·2026
Same author

Association of prenatal glycemic marker cumulative exposure with placental DNA methylation change.

The Journal of clinical endocrinology and metabolism·2026
Same author

Exploring the interplay among smoking, stress, and negative affect in patients with psychosis: An experience sampling method study.

European psychiatry : the journal of the Association of European Psychiatrists·2025
Same author

Effect of polygenic scores on the relationship between psychosis and cognition.

Translational psychiatry·2025

Related Experiment Video

Updated: Jul 25, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K

Deep Clinical Phenotyping of Schizophrenia Spectrum Disorders Using Data-Driven Methods: Marching towards Precision

Tesfa Dejenie Habtewold1, Jiasi Hao1, Edith J Liemburg2

  • 1Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

Journal of Personalized Medicine
|June 28, 2023
PubMed
Summary

This study identified distinct subtypes of schizophrenia spectrum disorders based on symptoms, cognition, and psychosocial function. These subtypes show varied courses and can be predicted by baseline factors, aiding precision psychiatry.

Keywords:
cognitive impairmentdata-driven methodsdeep phenotypingphenotypeprecision psychiatrypsychosisschizophrenia spectrum disorder

More Related Videos

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.2K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.7K

Related Experiment Videos

Last Updated: Jul 25, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.2K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.7K

Area of Science:

  • Psychiatry and Genetics
  • Clinical Psychology
  • Neuroscience

Background:

  • Schizophrenia spectrum disorders (SSD) exhibit significant heterogeneity, complicating traditional classification due to a lack of objective diagnostic criteria.
  • The multidimensional nature of SSD symptoms and associated factors contributes to diagnostic challenges.
  • Deep clinical phenotyping is crucial for understanding and subtyping SSD.

Purpose of the Study:

  • To provide an overview of findings from the Genetic Risk and Outcome of Psychosis (GROUP) cohort study.
  • To identify latent subtypes within schizophrenia spectrum disorders based on symptoms, cognitive impairments, and psychosocial functioning.
  • To explore the longitudinal course and predictors of these identified subtypes for advancing precision psychiatry.

Main Methods:

  • Utilized deep clinical phenotyping of schizophrenia spectrum disorders within the GROUP cohort.
  • Analyzed positive and negative symptoms, cognitive impairments, and psychosocial functioning (social inclusion, premorbid adjustment).
  • Employed latent variable modeling to identify distinct subtypes and analyzed longitudinal data to determine course and predictors.

Main Results:

  • Identified 3-4 latent subtypes for positive/negative symptoms, 4-6 for cognitive impairments, and 5 for psychosocial functioning.
  • Discovered that identified subtypes exhibited mixed profiles and diverse longitudinal courses (stable, deteriorating, relapsing, ameliorating).
  • Found that baseline positive/negative symptoms, premorbid adjustment, psychotic-like experiences, quality of life, and PRSSCZ significantly predicted these subtypes.

Conclusions:

  • The identified subtypes offer a more nuanced understanding of schizophrenia spectrum disorders beyond traditional classification.
  • These findings have clinical implications for precisely identifying high-risk groups and predicting disease prognosis.
  • This research supports the advancement of precision psychiatry by improving diagnostic accuracy and optimizing treatment selection for SSD.