Related Experiment Video

Updated: Jul 25, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.5K

Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle

Alexandru Florinel Oancea1,2, Raul Alexandru Jigoranu1,2, Paula Cristina Morariu1,3

  • 1Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.

Life (Basel, Switzerland)
|June 28, 2023
PubMed

Insights

Atrial fibrillation and chronic coronary syndrome share a bidirectional relationship, worsening each other. Managing shared risk factors and employing targeted therapies are crucial for patient prognosis.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Atrial fibrillation is a common arrhythmia.
  • Chronic coronary syndrome involves coronary ischemia.
  • These conditions have a complex, dual relationship.

Purpose of the Study:

  • To explore the intricate relationship between atrial fibrillation and chronic coronary syndrome.
  • To identify shared risk factors and pathophysiological mechanisms.
  • To discuss therapeutic strategies for managing this dual condition.

Main Methods:

  • Literature review of existing studies on atrial fibrillation and coronary artery disease.
  • Analysis of pathophysiological links, including atherosclerosis and myocardial oxygen supply-demand mismatch.
  • Examination of common risk factors like hypertension, obesity, diabetes, and dyslipidemia.

Main Results:

  • Atrial fibrillation can exacerbate coronary ischemia by increasing myocardial oxygen demand and accelerating atherosclerosis.
  • Chronic coronary syndrome can promote atrial fibrillation through altered cardiac conduction and ectopic activity.
  • Shared risk factors significantly contribute to the development and progression of both conditions.

Conclusions:

  • Breaking the vicious cycle requires comprehensive management of shared risk factors.
  • Pharmacological therapies, including antithrombotic strategies, need careful consideration of risks.
  • Interventional treatments like revascularization and catheter ablation are vital therapeutic options.

Keywords:
atrial fibrillationchronic coronary syndromecoronary artery diseasecoronary ischemiatriple antithrombotic therapy

More Related Videos

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.4K

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
22
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
15
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
33
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
11
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
14
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
28