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Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction
Anna F Sheptulina1,2, Karina Yu Antyukh3, Anton R Kiselev4
1Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia.
Life (Basel, Switzerland)
|June 28, 2023
Summary
Obesity is linked to skeletal muscle dysfunction and inflammation, impacting metabolic health. Steroids like glucocorticoids and sex steroids play a key role in this interaction, regardless of age.
Area of Science:
- Endocrinology
- Metabolic Health
- Skeletal Muscle Physiology
Background:
- Skeletal muscles and adipose tissue are endocrine organs producing myokines and adipokines.
- The interplay between adipose tissue and skeletal muscle influences metabolic health.
- Sarcopenia, muscle loss, is increasingly recognized in obesity across all ages, not just the elderly.
Purpose of the Study:
- To clarify mechanisms linking obesity and skeletal muscle dysfunction.
- To explore the role of steroids in the obesity-skeletal muscle-adipose tissue interaction.
- To highlight the importance of steroid hormones in metabolic regulation.
Main Methods:
- Review of current scientific literature.
- Analysis of endocrine, paracrine, and autocrine signaling pathways.
- Investigation of steroid hormone (glucocorticoids, sex steroids) effects.
Main Results:
- Obesity negatively impacts skeletal muscle function and promotes inflammation.
- Adipose tissue distribution (intramuscular, visceral) is critical for metabolic health.
- Steroids significantly influence adipose tissue and skeletal muscle mass and function.
Conclusions:
- Skeletal muscle dysfunction is a key factor in obesity pathogenesis.
- Steroids are crucial mediators in the interaction between adipose tissue and skeletal muscle in obesity.
- Understanding these interactions is vital for developing targeted obesity treatments.
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