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A Comprehensive Update of Various Attempts by Medicinal Chemists to Combat COVID-19 through Natural Products

Ayesha Rafiq1, Tooba Jabeen1, Sana Aslam2

  • 1Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.

Molecules (Basel, Switzerland)
|June 28, 2023
PubMed

Insights

Natural products show promise in combating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Research reviews natural compounds targeting key SARS-CoV-2 proteins, offering potential new treatments for COVID-19.

Area of Science:

  • * Virology and Natural Product Chemistry
  • * Drug Discovery and Development

Background:

  • * The COVID-19 pandemic, caused by SARS-CoV-2, continues to evolve, necessitating novel therapeutic strategies.
  • * Existing drug repurposing efforts have shown limited success against the widespread viral spread.
  • * There is a critical need for new treatments derived from natural sources.

Purpose of the Study:

  • * To review and consolidate existing literature on natural products with inhibitory activity against SARS-CoV-2.
  • * To explore various therapeutic approaches, including in vivo, in vitro, and in silico studies.
  • * To identify natural compounds targeting essential SARS-CoV-2 proteins.

Main Methods:

  • * Comprehensive literature search for studies on natural products and SARS-CoV-2.
  • * Analysis of in vivo, in vitro, and in silico research methodologies.
  • * Identification of natural compounds and their targeted viral proteins.

Main Results:

  • * Numerous natural compounds exhibit inhibitory effects against SARS-CoV-2.
  • * These compounds target critical viral proteins such as Mpro, PLpro, spike proteins, and RdRp.
  • * Sources of these compounds include plants, bacteria, algae, fungi, and marine organisms.

Conclusions:

  • * Natural products represent a promising avenue for developing new COVID-19 therapies.
  • * Targeting specific SARS-CoV-2 proteins with natural compounds offers a viable strategy.
  • * Further research into these natural agents could lead to effective treatments against SARS-CoV-2.
Keywords:
COVID-19SARS-CoV-2in silicoin vitroin vivomolecular dockingmolecular docking simulationsnatural products

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