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Related Experiment Videos

Lactate transfer across the perfused human placenta.

N P Illsley, R Wootton, P Penfold

    Placenta
    |May 1, 1986
    PubMed
    Summary

    This study investigated human placental lactate transfer. While a stereospecific carrier exists, most lactate moves across the placenta via non-carrier-mediated diffusion.

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    Biomarkers of abnormally invasive placenta.

    Placenta·2020

    Area of Science:

    • Obstetrics and Gynecology
    • Perinatal Medicine
    • Biochemistry

    Background:

    • Lactate is a key metabolite in fetal development.
    • Understanding transplacental lactate transfer is crucial for fetal well-being.

    Purpose of the Study:

    • To investigate the mechanisms of L-lactate transfer across the human placenta.
    • To determine the quantitative aspects of lactate transport in both maternal-to-fetal and fetal-to-maternal directions.

    Main Methods:

    • Utilized a novel in vitro dually-perfused human placental preparation.
    • Employed radiolabeled [14C]L-lactate to measure unidirectional flux.
    • Conducted stereospecificity and permeability experiments.

    Main Results:

    • Unidirectional L-lactate flux showed a linear dependence on L-lactate concentration.
    • Transfer rates were similar in both maternal-to-fetal and fetal-to-maternal directions.
    • Competition experiments indicated a stereospecific component, but diffusion appeared dominant.

    Conclusions:

    • A stereospecific carrier for lactate transport exists in the human placenta.
    • The primary mechanism for transplacental lactate transfer is non-carrier-mediated diffusion.

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