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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
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Reduction-Responsive Chitosan-Based Injectable Hydrogels for Enhanced Anticancer Therapy.

Trung Thang Vu1, Sonyabapu Yadav1, Obireddy Sreekanth Reddy2

  • 1Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.

Pharmaceuticals (Basel, Switzerland)
|June 28, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed novel chitosan-based injectable hydrogels for targeted cancer therapy. These smart hydrogels selectively release anticancer drugs like doxorubicin (DOX) at tumor sites, improving efficacy and reducing side effects.

Keywords:
chitosanclick chemistrydisulfide-based cross-linkerhydrogelsreduction-responsive

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Cancer Therapeutics

Background:

  • Selective drug delivery to tumors is crucial for enhancing chemotherapy efficacy and minimizing systemic toxicity.
  • Injectable hydrogels offer a promising platform for localized and controlled drug release.
  • Developing stimuli-responsive materials that release drugs in the tumor microenvironment is a key challenge.

Purpose of the Study:

  • To engineer reduction-responsive, chitosan-based injectable hydrogels for controlled doxorubicin (DOX) delivery.
  • To investigate the physicochemical properties and drug-loading capabilities of these novel hydrogels.
  • To evaluate the in vitro biocompatibility and anticancer efficacy of the DOX-loaded hydrogels.

Main Methods:

  • Chitosan derivatives were functionalized with norbornene groups.
  • Disulfide-based cross-linkers with tetrazine groups were synthesized.
  • Inverse electron demand Diels-Alder reaction was utilized for hydrogel formation.
  • Physicochemical properties (swelling, gelation, mechanical strength) and DOX loading efficiency were characterized.
  • In vitro drug release studies were conducted under various conditions (pH, DTT presence).
  • MTT assays were performed to assess cytotoxicity and anticancer activity on HEK-293 and HT-29 cell lines.

Main Results:

  • Injectable hydrogels were successfully synthesized with tunable gelation times (90-500 s) and mechanical strength (G'~350-850 Pa).
  • High doxorubicin (DOX) loading efficiency (≥92%) was achieved.
  • In vitro studies demonstrated pH- and reduction-responsive DOX release, with enhanced release at acidic pH and in the presence of DTT.
  • The hydrogels exhibited good biocompatibility and significant in vitro anticancer activity against HT-29 cancer cells.

Conclusions:

  • Reduction-responsive chitosan-based hydrogels are effective platforms for controlled doxorubicin delivery.
  • These hydrogels show potential for improving cancer treatment by enhancing local drug concentration and reducing systemic toxicity.
  • Further in vivo studies are warranted to validate their therapeutic potential in cancer therapy.