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Updated: Jul 25, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Development of Zeise's Salt Derivatives Bearing Substituted Acetylsalicylic Acid Substructures as Cytotoxic COX

Alexander Weninger1, Jessica Sagasser1, Victoria Obermoser1

  • 1Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI-Center for Molecular Biosciences Innsbruck, CCB-Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Pharmaceutics
|June 28, 2023
PubMed

Keywords:
COX-inhibitionZeise’s saltanticancerantiproliferative activitycapillary electrophoresischlorinationcyclooxygenase enzymefluorinationmethylationplatinum

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