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Thermal Measurement Techniques in Analytical Microfluidic Devices
Published on: June 3, 2015
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Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals
Marek Wesolowski1, Edyta Leyk1
1Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Pharmaceutics
|June 28, 2023
Summary
Coupling thermal analysis techniques like thermogravimetry (TG) with spectroscopic or chromatographic methods enhances data reliability. This approach precisely characterizes medicinal substances during heating, aiding pharmaceutical development and stability assessments.
Area of Science:
- Analytical Chemistry
- Materials Science
- Pharmaceutical Science
Background:
- Interpreting thermal analysis data requires multiple techniques to overcome single-method uncertainties.
- Coupled techniques are essential for accurate characterization of sample behavior during heating.
Purpose of the Study:
- To characterize thermal analysis techniques coupled with non-thermal methods.
- To highlight the importance of these coupled techniques in pharmaceutical technology.
Main Methods:
- Discusses coupled thermogravimetry (TG) with Fourier transform infrared spectroscopy (FTIR), TG with mass spectrometry (MS), and TG with gas chromatography/mass spectrometry (GC/MS).
- Explains design solutions for differential scanning calorimetry (DSC) interpretation using simultaneous FTIR and X-ray diffractometry (XRD).
Main Results:
- Coupled techniques precisely determine medicinal substance behavior during heating and identify volatile degradation products.
- Enables elucidation of thermal decomposition mechanisms and prediction of drug stability.
Conclusions:
- Combined thermal and non-thermal analyses are crucial for understanding and predicting the behavior of medicinal substances.
- These methods are vital for pharmaceutical formulation, shelf-life determination, and storage condition optimization.
Keywords:
DSCDSC–FTIR microspectroscopyDSC–XRDDSC–photovisualTGTG–FTIRTG–GC/MSTG–MScoupled techniquespharmaceuticalssimultaneous techniquesMore Related Videos
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