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Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
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Three Dimensional Printing and Its Applications Focusing on Microneedles for Drug Delivery
Suhair S Al-Nimry1, Rawand M Daghmash1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Pharmaceutics
|June 28, 2023
Summary
Three-dimensional (3D) printing offers a superior method for fabricating microneedles (MNs), enabling painless transdermal drug delivery. This advanced technique allows for precise, patient-tailored designs and efficient production of various MN types.
Area of Science:
- Biomaterials Science
- Pharmaceutical Technology
- Medical Device Engineering
Background:
- Microneedles (MNs) represent a minimally invasive transdermal drug delivery system for therapeutics like insulin and vaccines.
- Traditional MN fabrication methods (e.g., molding) are being surpassed by advanced techniques.
- Three-dimensional (3D) printing offers enhanced precision, efficiency, and customization in MN production.
Purpose of the Study:
- To review the benefits and drawbacks of 3D printing for MN fabrication.
- To explore various 3D printing methods and their application in creating different MN types (hollow, solid).
- To discuss the characterization and transdermal delivery applications of 3D-printed MNs.
Main Methods:
- Review of current literature on 3D printing technologies applied to microneedle fabrication.
- Analysis of different 3D printing techniques (e.g., stereolithography, inkjet printing).
- Examination of material selection and design parameters for 3D-printed MNs.
Main Results:
- 3D printing provides superior accuracy, speed, and production efficiency compared to conventional methods.
- Patient-tailored MNs with specific dimensions and dosages can be designed and manufactured.
- Diverse MN structures, including hollow and solid designs, can be produced using various materials.
Conclusions:
- 3D printing is revolutionizing the fabrication of microneedles for advanced transdermal drug delivery.
- This technology enables personalized medicine through custom-designed MNs and precise drug dosages.
- 3D-printed MNs hold significant potential in pharmaceutical, cosmeceutical, and medical applications.
