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Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the

Daniel L Pouliquen1, Koraljka Gall Trošelj2, Ruby John Anto3

  • 1Université d'Angers, Inserm, CNRS, Nantes Université, CRCI2NA, F-49000 Angers, France.

Pharmaceutics
|June 28, 2023
PubMed

Insights

Curcuminoids show diverse anti-cancer effects by inhibiting tumor pathways and reversing drug resistance. Ongoing research explores their role in metabolic reprogramming and future therapeutic potential.

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Curcuminoids, including curcumin and synthetic analogs, have seen a surge in cancer research over 20 years.
  • These compounds exhibit diverse inhibitory effects on pathways crucial for carcinogenesis and tumor progression.

Purpose of the Study:

  • To chronologically review discoveries and update in vivo effects of curcuminoids in cancer.
  • To explore curcuminoids' role in modulating metabolic reprogramming in cancer.
  • To examine curcuminoids as chemosensitizers to overcome multidrug resistance.

Main Methods:

  • Literature review of experimental and clinical studies on curcuminoids in cancer research.
  • Analysis of data on curcuminoids' effects on carcinogenesis, tumor progression, and metabolic pathways.
  • Investigation of curcuminoids' efficacy in reversing multidrug resistance in combination therapies.

Main Results:

  • Curcuminoids demonstrate a broad spectrum of inhibitory actions against multiple cancer-related pathways.
  • Emerging evidence highlights their capacity to modulate cancer cell metabolic reprogramming.
  • Curcuminoids show promise in resensitizing cancer cells to conventional chemotherapy, overcoming multidrug resistance.

Conclusions:

  • Curcuminoids represent a significant area of cancer research with established and emerging therapeutic applications.
  • Further investigation into their pleiotropic effects, particularly metabolic modulation and chemosensitization, is warranted.
  • Future research should focus on translating these findings into effective clinical strategies for cancer treatment.
Keywords:
cancerchemosensitizationcurcumincurcuminoidsmetabolic reprogrammingsignaling pathways

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