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Moisture Behavior of Pharmaceutical Powder during the Tableting Process

Komlan Koumbogle1, Ryan Gosselin1, François Gitzhofer1

  • 1Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500 Boulevard de l'Université, Sherbrooke, QC J1K 2R1, Canada.

Pharmaceutics
|June 28, 2023
PubMed
Summary

Powder moisture accumulation during tableting can cause tablet sticking. This study simulated and measured moisture behavior, revealing that evaporated moisture at the punch-tablet interface induces capillary forces, leading to sticking.

Keywords:
COMSOL MultiphysicsDrucker–Prager cap (DPC)NIR penetration depthPharmaceuticsair and moisture (HAM)compactionfinite element analysisheatmoisturerelative densitystickingtabletingtemperature field

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