Recent Advances in Nanoformulations for Quercetin Delivery

Area of Science:

• Pharmacology and Drug Delivery
• Materials Science
• Nanotechnology

Background:

• Quercetin (QUE), a potent flavonol, possesses significant pharmacological properties.
• Low aqueous solubility and extensive first-pass metabolism of QUE hinder its oral administration and therapeutic effectiveness.

Purpose of the Study:

• To review the potential of various nanoformulations for improving Quercetin's bioavailability.
• To explore advanced drug delivery nanosystems for efficient encapsulation, targeting, and controlled release of QUE.

Main Methods:

• Overview of primary nanosystem categories, formulation processes, and characterization techniques.
• Focus on lipid-based nanocarriers (liposomes, NLCs, SLNs) and polymer-based nanocarriers (micelles, hydrogels).
• Discussion of alternative formulations like cyclodextrins, niosomes, and nanoemulsions for diverse administration routes.

Main Results:

• Lipid-based nanocarriers enhance QUE's oral absorption, targeting, antioxidant activity, and provide sustained release.
• Polymer-based nanocarriers improve the Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADME(T)) profile of QUE.
• Various nanosystems offer promising strategies for overcoming QUE's formulation challenges.

Conclusions:

• Advanced drug delivery nanosystems are crucial for developing effective Quercetin dosage forms.
• Nanoformulations significantly enhance QUE bioavailability, efficacy, and pharmacokinetic profiles.
• This review highlights the role of nanotechnology in optimizing Quercetin delivery for therapeutic applications.