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Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex
Caio Junji Tanaka1,2,3, José Augusto Rodrigues2,3, João Marcos Spessoto Pingueiro2
1School of Dentistry, Mogi das Cruzes University, Mogi das Cruzes 08780-911, Sao Paulo, Brazil.
Pharmaceutics
|June 28, 2023
Summary
Surface pre-reacted glass (S-PRG) coatings show antimicrobial potential against periodontitis-causing bacteria. This study found S-PRG coatings significantly reduced pathogenic bacterial counts in multispecies biofilms, indicating their efficacy in modifying oral microbial profiles.
Area of Science:
- Dental Materials Science
- Microbiology
- Periodontology
Background:
- Bioactive materials releasing fluoride are common in dentistry.
- Limited research exists on the antimicrobial effects of surface pre-reacted glass (S-PRG) coatings on periodontopathogenic biofilms.
Purpose of the Study:
- To evaluate the antibacterial activity of S-PRG fillers on the microbial profile of multispecies subgingival biofilms.
- To assess the impact of S-PRG coatings on periodontopathogenic bacteria in vitro.
Main Methods:
- A 33-species periodontitis-related biofilm was cultivated for 7 days using a Calgary Biofilm Device (CBD).
- S-PRG coating was applied and photo-activated on test group CBD pins; control group received no coating.
- Bacterial counts, metabolic activity, and microbial profiles were analyzed using colorimetric assay and DNA-DNA hybridization.
Main Results:
- The S-PRG coating group exhibited a 25.7% reduction in bacterial activity compared to the control.
- Statistically significant reductions were observed for 15 key periodontopathogenic species (p ≤ 0.05).
- S-PRG coating altered the subgingival biofilm composition, reducing pathogen colonization.
Conclusions:
- Bioactive S-PRG coatings demonstrate significant in vitro antibacterial activity against periodontopathogenic biofilms.
- S-PRG coatings effectively modify the microbial profile of subgingival biofilms, reducing key pathogens.
- These findings suggest potential clinical applications for S-PRG coatings in managing periodontal disease.
