Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amphetamine and the overtraining reversal effect.

I Weiner, E Ben Horin, J Feldon

    Pharmacology, Biochemistry, and Behavior
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia.

    Molecular psychiatry·2017
    Same author

    Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia.

    Translational psychiatry·2016
    Same author

    Effects of withdrawal from repeated amphetamine exposure in peri-puberty on neuroplasticity-related genes in mice.

    Neuroscience·2013
    Same author

    Schizophrenia: do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models.

    Translational psychiatry·2012
    Same author

    Distribution of latent inhibition by interupting the subicular input to nucleus accumbens and its antagonism by haloperidol.

    Journal of psychopharmacology (Oxford, England)·2012
    Same author

    Schizophrenia-relevant behaviors in a genetic mouse model of constitutive Nurr1 deficiency.

    Genes, brain, and behavior·2011
    Same journal

    Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2026
    See all related articles

    d-amphetamine significantly improved reversal learning in rats mastering a brightness discrimination task. However, overtraining impaired reversal learning in amphetamine-treated rats while benefiting saline-injected controls.

    Area of Science:

    • Behavioral neuroscience
    • Animal learning and behavior
    • Pharmacology

    Background:

    • Discrimination learning and reversal learning are fundamental concepts in behavioral psychology.
    • The Y-maze is a common apparatus for studying spatial and non-spatial learning in rodents.
    • Overtraining and pharmacological agents can modulate learning and memory processes.

    Purpose of the Study:

    • To investigate the effects of d-amphetamine on reversal learning in rats.
    • To examine the impact of overtraining on reversal learning, both with and without d-amphetamine.
    • To assess the influence of d-amphetamine on initial brightness discrimination acquisition.

    Main Methods:

    • Rats were trained on a two-choice simultaneous brightness discrimination task in a Y-maze.

    Related Experiment Videos

  • Two groups were established: Mastery (trained to criterion) and Overtraining (additional 110 trials).
  • Animals underwent reversal learning, with some receiving d-amphetamine (1 mg/kg) or saline.

    • Main Results:

    • d-amphetamine significantly facilitated reversal learning in the Mastery group.
    • Overtraining improved reversal learning in saline-treated rats but impaired it in d-amphetamine-treated rats.
    • d-amphetamine also enhanced the acquisition of the initial brightness discrimination.

    Conclusions:

    • d-amphetamine enhances both initial learning and reversal learning of brightness discrimination in rats.
    • Overtraining's effect on reversal learning is dependent on the presence of d-amphetamine, suggesting complex interactions.
    • These findings highlight the modulatory role of amphetamines in cognitive flexibility and learning processes.