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Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Updated: Jun 2, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Electro-Responsive Conductive Blended Hydrogel Patch.

Jang Ho Ha¹, Jae Hyun Lim², Jong Min Lee³

¹Department of Mechanical Engineering, Sogang University, Seoul 04107, Republic of Korea.

|June 28, 2023

Summary

This summary is machine-generated.

Researchers developed a novel conductive blended hydrogel for transdermal drug delivery. This electro-responsive hydrogel patch shows controllable drug release, enhancing smart drug delivery system applications.

Keywords:

alginate drug release electro-responsive blended hydrogel gelatin methacrylate silver nanowire

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Last Updated: Jun 2, 2026

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Area of Science:

Biomaterials Science
Materials Chemistry
Drug Delivery Systems

Background:

Hydrogels are widely researched for transdermal drug delivery systems (TDDS).
Previous studies focused on blending hydrogels to improve physical/chemical properties.
Limited research exists on enhancing hydrogel electrical conductivity and drug delivery capabilities.

Purpose of the Study:

To develop a conductive blended hydrogel with improved electrical properties for TDDS.
To investigate the potential of silver nanowires (AgNW) and gelatin methacrylate (GelMA) in enhancing hydrogel performance.
To demonstrate electro-responsive, on-off controllable drug release from the developed hydrogel patch.

Main Methods:

Fabrication of a blended hydrogel by mixing alginate, GelMA, and AgNW.
Characterization of the blended hydrogel's tensile strength and electrical conductivity.
Evaluation of the hydrogel patch's drug release profile under electrical stimulation (ES).

Main Results:

Blending GelMA increased the tensile strength of hydrogels by 1.8 times.
Addition of AgNW enhanced electrical conductivity by 18 times.
The GelMA-alginate-AgNW (Gel-Alg-AgNW) hydrogel patch demonstrated controllable doxorubicin release (57%) upon ES.

Conclusions:

The developed electro-responsive blended hydrogel exhibits enhanced mechanical and electrical properties.
The Gel-Alg-AgNW hydrogel patch enables precise, on-off control over drug release via electrical stimulation.
This smart hydrogel patch holds significant promise for advanced transdermal drug delivery applications.