DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond

Area of Science:

• Vaccinology
• Molecular Biology
• Immunology

Background:

• The SARS-CoV-2 pandemic accelerated vaccine development.
• DNA vaccines offer potential advantages over traditional vaccine platforms.

Purpose of the Study:

• To review DNA vaccines for SARS-CoV-2 that reached Phase 2 or beyond.
• To compare devices used in clinical trials for user needs and cost-effectiveness.

Main Methods:

• Comprehensive literature review of DNA vaccine candidates.
• Comparative analysis of delivery devices based on user requirements and economic factors.

Main Results:

• Several DNA vaccines advanced to clinical trials, with some authorized.
• The GeneDerm suction device demonstrated significant benefits for large-scale vaccination efforts.

Conclusions:

• DNA vaccines present a promising, rapidly producible, and stable option for pandemic preparedness.
• The GeneDerm device enhances the feasibility of international DNA vaccine deployment.