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Related Concept Videos

Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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2D-3D-Convertible, pH-Responsive Lipid Nanosheets.

Wancheng Zhang1, Shutaro Takahashi1, Naohiko Shimada1

  • 1Department of Life Science and Technology, Tokyo Institute of Technology, 4259 B-57 Nagatsuta, Midori-ku, Yokohama, 226-8501, Japan.

Small (Weinheim an Der Bergstrasse, Germany)
|June 28, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed stable 2D lipid nanosheets that transform into cell-sized vesicles with pH changes. This breakthrough offers potential for advanced drug delivery systems and artificial cells.

Keywords:
2D-3D conversioncationic copolymerslipid nanosheetsrobust pH responsivenessvesosomes

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Two-dimensional (2D) nanosheets from amphiphilic molecules show promise for biomedical uses.
  • Challenges exist in forming and stabilizing these nanosheets under physiological conditions.

Purpose of the Study:

  • To develop robust, structurally stable lipid nanosheets.
  • To achieve reversible conversion of nanosheets to cell-sized vesicles via pH changes within the physiological range.

Main Methods:

  • Utilized a dual anchoring system with the membrane disruptive peptide E5 and a cationic copolymer.
  • Anchored components onto lipid membranes to control nanosheet formation and stability.

Main Results:

  • Successfully developed lipid nanosheets with high structural stability.
  • Demonstrated robust, reversible conversion to cell-sized vesicles triggered by physiological pH fluctuations.

Conclusions:

  • The developed dual anchoring system provides a method for creating dynamic lipidic nanodevices.
  • Potential applications include advanced drug delivery systems and artificial cells (vesosomes).