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Related Experiment Video

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Dietary Calcium and Risk of Microscopic Colitis.

Robert S Sandler^1,2, Shan Sun¹, Temitope O Keku^1,2

¹Center for Gastrointestinal Biology and Disease, Chapel Hill, North Carolina, USA.

Clinical and Translational Gastroenterology

|June 28, 2023

Summary

This summary is machine-generated.

Higher dietary calcium intake may reduce microscopic colitis (MC) risk. This study found lower calcium consumption in MC patients and linked calcium to gut bacteria changes, suggesting a dietary role in MC development.

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Area of Science:

Gastroenterology
Microbiome research
Nutritional science

Background:

Microscopic colitis (MC) is a growing cause of watery diarrhea, especially in the elderly.
The impact of diet on MC pathogenesis remains understudied.

Purpose of the Study:

To investigate the association between dietary intake and microscopic colitis (MC).
To explore the relationship between diet, gut microbiota, and MC risk.

Main Methods:

A case-control study was performed with 106 MC cases and 215 controls.
Dietary intake was assessed using a validated food frequency questionnaire.
Colonic biopsies were analyzed for adherent microbes using 16s rRNA sequencing.

Main Results:

Individuals in the highest quartile of dietary calcium intake showed a reduced risk of MC.
Dietary calcium intake was significantly associated with the abundance of specific gut bacteria (Actinobacteria, Coriobacteriales).
MC cases exhibited lower dietary calcium intake compared to controls.

Conclusions:

Dietary calcium intake may play a role in the risk of developing microscopic colitis.
Alterations in gut microbiota composition may be influenced by dietary factors, potentially impacting MC risk.