[Isosorbide dinitrate and bupranolol in the therapy of coronary heart disease (author's transl)]

Area of Science:

• Cardiology
• Pharmacology

Background:

• Coronary heart disease (CHD) involves detrimental hemodynamic changes during stress.
• Current management strategies aim to mitigate these responses.

Purpose of the Study:

• To evaluate the efficacy of a combined long-acting nitrite and beta-receptor blocker therapy.
• To assess the impact of this combination on hemodynamic responses to physical and mental stress in CHD patients.

Main Methods:

• A study involving sixteen patients with coronary heart disease and three healthy volunteers.
• Administration of a combination of a long-acting nitrite and a beta-receptor blocking agent.
• Monitoring hemodynamic changes following physical and mental stress induction.

Main Results:

• The drug combination demonstrated effectiveness in reducing hemodynamic alterations.
• Significant diminishment of adverse hemodynamic changes was observed after both physical and mental stressors.
• The treatment was well-tolerated by the study participants.

Conclusions:

• Combined therapy with long-acting nitrite and beta-receptor blockers is effective in managing stress-induced hemodynamic changes in coronary heart disease.
• Findings support the potential of this therapeutic approach in mitigating CHD pathogenetic mechanisms related to stress.