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Antidepressant Use and Lung Cancer Risk and Survival: A Meta-analysis of Observational Studies
Eunkyung Lee1, Yongho Park2, David Li1
1Department of Health Sciences, College of Health Professions and Sciences, University of Central Florida, Orlando, Florida.
Antidepressant (AD) use was linked to an 11% increased risk of lung cancer, with serotonin and norepinephrine reuptake inhibitors (SNRIs) showing a higher association. Further research is needed to understand this link, especially concerning environmental factors.
Area of Science:
- Oncology
- Pharmacology
- Epidemiology
Background:
- Antidepressants (ADs) have shown potential anticancer effects in preclinical models.
- The impact of ADs on lung cancer incidence and survival remains unclear.
- Observational studies suggest a possible link between AD use and cancer risk.
Conclusions:
- AD use, particularly SNRIs, may be associated with an elevated risk of lung cancer.
- Concerns are raised regarding AD treatment in individuals vulnerable to lung cancer.
- Further research is warranted to explore the interplay of ADs, environmental factors, and lung cancer risk.
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